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Comment & Response
September 4, 2013

Genetic Variants Associated With Susceptibility to Helicobacter pylori

Author Affiliations
  • 1Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle
  • 2Division of Allergy and Infectious Diseases, University of Washington, Seattle
JAMA. 2013;310(9):976. doi:10.1001/jama.2013.194762

To the Editor The study by Dr Mayerle and collegues1 found a strong association between variants at the toll-like receptor 10, 1, and 6 (TLR10/1/6) locus on chromosome 4 and Helicobacter pylori serologic status, which contributes to the understanding of host susceptibility to a common infectious disease. During the process of evaluating the functional significance of their finding, the authors presented results that indicate that a single-nucleotide polymorphism within this locus (rs10004195), which was identified as having the strongest association with H pylori seroprevalence, may be an expression quantitative trait locus causing reduced expression of TLR1. They suggested that decreased TLR1 messenger RNA expression or defective protein function, or both, might be responsible for the observed association with protection from the acquisition of H pylori seropositivity.