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JAMA Clinical Evidence Synopsis
September 18, 2013

Antioxidant Supplements to Prevent Mortality

Author Affiliations
  • 1The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
JAMA. 2013;310(11):1178-1179. doi:10.1001/jama.2013.277028

Clinical Question  Are antioxidant supplements associated with higher or lower all-cause mortality?

Bottom Line  Antioxidant supplements are not associated with lower all-cause mortality. Beta carotene, vitamin E, and higher doses of vitamin A may be associated with higher all-cause mortality.

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