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To the Editor The randomized controlled trial of early parenteral nutrition in patients with critical illness1 targeted calories, but the nutrient that is most lacking in critical illness and whose provision is most likely to be of benefit is protein. When hydrated, free amino acid mixtures provide 17% less protein substrate than formed dietary proteins.2
Hoffer LJ. Early Parenteral Nutrition in Critical Illness. JAMA. 2013;310(11):1183. doi:10.1001/jama.2013.276761
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