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Comment & Response
October 23/30, 2013

Risks Associated With Opioid Use

Author Affiliations
  • 1Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania
JAMA. 2013;310(16):1737. doi:10.1001/jama.2013.277305

To the Editor Dr Dowell and colleagues1 discussed the recent increase in opioid-related deaths and attributed it primarily to increased opioid prescribing for chronic, nonmalignant pain. The authors stated that long-term opioid therapy ultimately leads to tolerance and this in turn triggers opioid dose escalation, which is the major risk factor for opioid overdose.