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Comment & Response
November 6, 2013

Acute Ischemic Stroke and Timing of Treatment

Author Affiliations
  • 1University of Texas Health Science Center, Houston
JAMA. 2013;310(17):1855-1856. doi:10.1001/jama.2013.278893

To the Editor Dr Saver and colleagues1 used the Get With The Guidelines–Stroke (GWTG-Stroke) registry to investigate the association of time to tissue-type plasminogen activator (tPA) treatment and outcomes from stroke. However, the authors did not address the handling of transient ischemic attacks (TIAs) and stroke mimics within the registry, which is a potential confounder in the abstraction method used in the study.