Each year at the time of the American Heart Association (AHA) Scientific Sessions, we devote an issue of JAMA to cardiovascular disease (CVD). The issue provides an opportunity to focus on some of the latest findings and to provide viewpoints on important challenges ahead. This year, as tens of thousands gather at the AHA meeting in Dallas, Texas, to share their work and learn from others, we acknowledge and celebrate the dedication of the researchers responsible for this important work.