A recent search has uncovered 157 genetic variations that modify levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, and total cholesterol (Global Lipids Genetics Consortium et al. Nat Genet. 2013;45:1274-1283).
A worldwide team of scientists pooled genetic and clinical information from 188 577 European-ancestry individuals and 7898 individuals of non-European ancestry to identify the changes, 62 of which are located within regions not previously linked to lipids. Many of the changes were also associated with coronary artery disease, type 2 diabetes, obesity, and hypertension. All but one of the variants associated with blood lipids were near protein-coding regions of DNA.
Hampton T. Study Reveals Genetic Variations Linked with Lipid Levels. JAMA. 2013;310(22):2389. doi:10.1001/jama.2013.283990
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