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Comment & Response
December 18, 2013

Weight Loss Treatment in Obese Adults—Reply

Author Affiliations
  • 1Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts
  • 2Department of Medicine, Weill Cornell Medical College, New York, New York
JAMA. 2013;310(23):2568. doi:10.1001/jama.2013.282261

In Reply As Dr Gadde correctly notes, we stated in our Commentary that 58 participants in the trial1 were nonadherent to the treatment protocol for various reasons. In the trial, 48 participants dropped out, of whom 41 returned for the final visit. Therefore, 7 were lost to follow-up.

The authors identified an additional 10 participants who discontinued use of the blinded study drug but remained in the study as “study completers.” They only counted the 48 patients as dropouts in calculating the study completion rate of 96.9%. The 96.9% therefore included the 10 participants who discontinued taking the study drug yet completed study visits to the end of the trial.