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Lab Reports
January 1, 2014

Stress Affects Expression of Inflammatory Genes in Immune Cells

JAMA. 2014;311(1):19. doi:10.1001/jama.2013.285447

Immune cells in humans and mice under stress demonstrate increased expression of genes that activate inflammation and decreased expression of genes that suppress inflammation, reports a team led by researchers at the Ohio State University, in Columbus, and the University of California, Los Angeles (Powell ND et al. Proc Natl Acad Sci U S A. 2013;110[41]:16574-16579). The investigators’ analysis included individuals who were subject to chronic social stress due to low socioeconomic status and mice that were subject to repeated social defeat.