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Comment & Response
January 1, 2014

Combination Pill for Cardiovascular Disease—Reply

Author Affiliations
  • 1International Centre for Circulatory Health, Imperial College London, London, England
  • 2George Institute for Global Health, Sydney, Australia
JAMA. 2014;311(1):93-94. doi:10.1001/jama.2013.283146

In Reply Drs Tsujimoto and Yamamoto-Honda note that improvements in adherence are of benefit in terms of increasing uptake of proven antiplatelet therapy, but question the importance of the improvements in mean LDL-C level and SBP. In contrast to their suggestion, in high-risk cardiovascular patients there is clear evidence of benefits of blood pressure lowering in patients without hypertension and of more vs less blood pressure lowering1-3; similarly, there are benefits of LDL-C level lowering in patients without hyperlipidemia and of more vs less LDL-C level lowering.4,5

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