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Book and Media Reviews
February 13, 2008

Cardiovascular Regeneration and Stem Cell Therapy

JAMA. 2008;299(6):700-701. doi:10.1001/jama.299.6.700

Stem cell biology and its potential for regenerative medicine is an exciting and fast-moving topic. The cardiovascular community was among the first to translate early experimental results into clinical applications. In fact, large trials are ongoing in which bone marrow cells are used to treat patients after myocardial infarction. However, the efficacy, the potential mechanisms, and the possible risks associated with this treatment are still a matter of controversy. In addition, recent findings suggest that, similar to the central nervous system, endogenous progenitors/stem cells may be present in the adult heart and that these cells could be further exploited for therapeutic purposes. Therefore, Cardiovascular Regeneration and Stem Cell Therapy, edited by Drs Leri, Anversa, and Frishman, is timely and interesting because it summarizes the current data on these topics.