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The World in Medicine
February 20, 2008

Drug-Resistant Bacteria

JAMA. 2008;299(7):755. doi:10.1001/jama.299.7.755-b

A naturally occurring chemical in the skin of amphibians may inhibit some multidrug-resistant strains of bacteria associated with nosocomial infection, according to new research reported by Italian investigators (Mangoni ML et al. Antimicrob Agents Chemother. 2008;52[1]:85-91).

Previous research had found that amphibian skin is a rich source of antimicrobial peptides. In this study, the researchers tested 5 peptides from 3 frog and toad species for activity against multidrug-resistant clinical isolates of bacteria often associated with hospital acquired infections (Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii).