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February 27, 2008

False-Positive Rate of Posttherapy Positron Emission Tomography in Cervical Cancer

JAMA. 2008;299(8):898. doi:10.1001/jama.299.8.898-a

To the Editor: In their study of tumor response and survival in cervical carcinoma, Dr Schwarz and colleagues1 found a 3-year cause-specific survival of 43% in patients with cervical cancer who had persistent positron emission tomography (PET) with F-18 fluorodeoxyglucose (FDG) uptake in the irradiated region following therapy. However, it is not clear what percentage of patients with persistent FDG activity had truly persistent neoplastic disease.