To the Editor: In their Commentary,
Dr Brayne and colleagues1 raise many critical issues regarding the need to identify effective methods to screen for dementia. We suggest that this include detection of the mild cognitive impairment (MCI) syndrome, where there is objective decline in cognitive functioning. Longitudinal clinical studies indicate that participants with amnestic MCI have a substantially increased rate of progression to clinically probable Alzheimer disease.2
Rafii MS, Galasko D. Primary Care Screening for Dementia and Mild Cognitive Impairment. JAMA. 2008;299(10):1132–1134. doi:10.1001/jama.299.10.1132-a
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