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Featured Clinical Reviews

March 19, 2008

Genomic Profiles for Disease Risk: Predictive or Premature?

Author Affiliations

Author Affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.

JAMA. 2008;299(11):1353-1355. doi:10.1001/jama.299.11.1353

There has been a recent explosion of commercial availability of genomic “tests” for diseases, conditions, traits, and ancestry. Dozens of companies advertise their services directly to consumers who, if they are willing to provide a DNA sample (usually from saliva) and are also willing to pay the charges, can obtain genetic information about various health conditions. These “conditions” range from the tendency to form wet vs dry earwax to risk for significant adult-onset diseases (Table).1

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