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Lab, Field, & Clinic
March 19, 2008

Researchers Create Artificial DNA Bases

JAMA. 2008;299(11):1251. doi:10.1001/jama.299.11.1251

The creation of 2 artificial DNA building blocks gives researchers the capability of increasing DNA's information potential and may make it possible to synthesize proteins with novel properties (Leconte AM et al. J Am Chem Soc. 2008;130[7]:2336-2343).

Like DNA's natural base-pair constituents, guanine pairing with cytosine and adenine with thymine, the additional DNA nucleotides pair up and could allow researchers to create unique DNA molecules with tailor-made binding or enzymatic activities for use in the laboratory and the clinic, said principal investigator and chemist Floyd Romesberg, PhD, of Scripps Research Institute in La Jolla, Calif.