To the Editor: Dr Pandharipande and colleagues1 studied the effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients and found that the use of dexmedetomidine infusion resulted in more days alive without delirium or coma and more time at the targeted level of sedation. However, because of the lorazepam dosing strategy we believe that the results of this trial have limited generalizability.
Dotson B, Peeters MJ. Sedation With Dexmedetomidine vs Lorazepam in Mechanically Ventilated Patients. JAMA. 2008;299(13):1540–1542. doi:10.1001/jama.299.13.1540-a
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