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January 22/29, 2014

From JAMA’s Daily News Site

Author Affiliations

Copyright American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(4):348. doi:10.1001/jama.2013.286120

The sleeping giant of HIV infection—a reservoir of viral DNA that lies dormant in human immune cells—could be far larger than previously believed.

A recent study showed that the reservoir, consisting of proviruses integrated into resting CD4 immune cells, may be 60 times larger than scientists had estimated. Antiretroviral therapy kills replicating HIV but not the latent proviruses, which pose a major barrier to eradicating the virus from the body and curing infection. The investigators would like to use their findings to develop better ways to measure the size of the latent reservoir in patients in future trials.

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