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The World in Medicine
April 16, 2008

Testosterone and Depression

JAMA. 2008;299(15):1764. doi:10.1001/jama.299.15.1764-d

Older men with lower levels of free testosterone may be more likely to experience depression than are men with higher levels of the sex hormone, according to a study by Australian scientists (Almeida O et al. Arch Gen Psychiatry. 2008;65[3]:283-289).

The study involved nearly 4000 men aged 71 to 89 years, 203 of whom met criteria for depression. After controlling for such factors as education level and cognitive scores, the researchers found that the odds of depression in men with a free testosterone concentration in the lowest quintile (<6 ng/dL) was nearly 3 times higher than that of men with a free testosterone concentration of at least 10 ng/dL.