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Book and Media Reviews
May 21, 2008

Endothelial Biomedicine

JAMA. 2008;299(19):2328. doi:10.1001/jama.299.19.2328

The endothelium is a highly complex, integrated system that lines the body's blood vessels, separating the intravascular and extravascular spaces into compartments and regulating transport between them. In many disease states, endothelial damage contributes substantially to clinical pathophysiology.

To describe Endothelial Biomedicine as a comprehensive textbook on the function of the endothelium in health and its dysfunction in disease may understate the value of this remarkable text. In this first-ever systematic integration of what has been learned about the endothelium as it relates to the traditional medical disciplines, the editor establishes endothelial biomedicine as an entity unto itself—providing it with a history, setting forth a body of knowledge, establishing a research agenda, and conveying how education in the field should proceed.