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May 28, 2008

Glucose-Insulin-Potassium Therapy in Patients With STEMI—Reply

JAMA. 2008;299(20):2385-2388. doi:10.1001/jama.299.20.jlt0528-e

In Reply: Dr Selker and colleagues, Dr Opie, and Drs Arora and Katragadda suggest that GIK infusion in acute MI is more likely to be beneficial when given before reperfusion therapy but that in our present study GIK was used primarily after reperfusion. However, we found no benefit of GIK therapy in any subgroup of interest (all of which were sizable given our total population of 22 943 patients), including those who underwent reperfusion therapy (n = 18 735), received primary PCI (n = 2626), underwent reperfusion after randomization (n = 10 041) so that GIK was administered before or concurrently with reperfusion therapy, or were enrolled in ECLA centers (n = 3798) (Figure).