To the Editor: Dr Heiss and colleagues1 studied the health risks and benefits after stopping estrogen and progestin for participants in the Women's Health Initiative (WHI) trial. They reported that the lower risk of colorectal cancer that had been observed in women prescribed conjugated equine estrogens plus medroxyprogesterone acetate compared with women assigned to placebo during the trial phase had disappeared within 3 years of discontinuing hormone replacement therapy.
Odell TW. Colorectal Cancer in Women After Stopping Postmenopausal Hormone Therapy. JAMA. 2008;299(23):2744–2745. doi:10.1001/jama.299.23.2744-a
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