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June 18, 2008

SSRI Tapering and Suicidal Ideation in the TORDIA Study for Treatment of Depressed Adolescents—Reply

JAMA. 2008;299(23):2745-2746. doi:10.1001/jama.299.23.2746-a

In Reply: We appreciate the comments of Drs Anghelescu and Regen regarding the TORDIA study. With respect to the switching strategy, we chose a conservative approach in this adolescent population rather than extrapolate from a strategy used in adults. Because our study was not placebo-controlled, the results from TORDIA cannot directly address the question of suicidality and antidepressant use. However, prospective studies specifically designed to address this issue are warranted.