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June 25, 2008

Survival for Patients With Pancreatic Cancer After Addition of Gemcitabine to Fluorouracil Chemoradiation

JAMA. 2008;299(24):2852-2853. doi:10.1001/jama.299.24.2852-a

To the Editor: In their randomized controlled trial, Dr Regine and colleagues1 compared the effects of gemcitabine and fluorouracil on survival after curative-intent resection of pancreatic adenocarcinoma followed by chemoradiation. The study found a survival benefit associated with the addition of gemcitabine, but this was not statistically significant. Of the patients, 66% had nodal metastases and 34% had microscopically positive margins, but lymph node examination rates and details about number of lymph nodes positive for metastatic cancer were not shown.