To the Editor: Dr Assié and colleagues1 reported a significant association between germline homozygosity in the human genome and increased cancer risk. They also reported an increased loss of heterozygosity (LOH) in cancer cells at the same sites as those of increased genome homozygosis. These findings are important for consanguineous populations, and the authors cited studies that showed an increased risk of cancer in inbreeding populations. However, they have considered only studies from Pakistan and Croatia, which are supportive of their findings.
Denic S, Nagelkerke N, Nicholls MG. Germline Genomic Homozygosity and Cancer Risk. JAMA. 2008;300(2):169–170. doi:10.1001/jama.300.2.169-b
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