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The World in Medicine
July 16, 2008

Breast Cancer Prognosis

JAMA. 2008;300(3):271. doi:10.1001/jama.300.3.271-d

Scientists from Finland have identified a common genetic mutation in a gene called NQO1 that strongly predicts poor survival in women with breast cancer who carry 2 copies of this mutation (Fagerholm R et al. Nat Genet. 10.1038/ng.155 [published ahead of print May 30, 2008]. NQO1 encodes an enzyme that protects cells from oxidative stress and carcinogenesis, and cells of women with 2 copies of the mutation (called NQO1*2) have no measurable NQO1 enzyme activity.