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October 8, 2008

Reductions in Incidence of Invasive Group B Streptococcal Disease in the United States—Reply

JAMA. 2008;300(14):1649-1650. doi:10.1001/jama.300.14.1650-a

In Reply: Both letters question whether prevention of early-onset group B streptococcal disease by intrapartum antibiotic prophylaxis resulted in important disease reductions. From 1993 to 2005, the Active Bacterial Core surveillance (ABCs) documented an 80% decline in invasive early-onset group B streptococcal disease incidence from 1.66 to 0.35 cases per 1000 live births.1 This coincided with widespread uptake of intrapartum antibiotic prophylaxis following issuance of consensus perinatal group B streptococcal disease prevention guidelines in 1996 and a guidelines update in 2002.