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October 15, 2008

Escitalopram, Problem-Solving Therapy, and Poststroke Depression

JAMA. 2008;300(15):1757-1759. doi:10.1001/jama.300.15.1757-b

To the Editor: The study of prevention of poststroke depression by Dr Robinson and colleagues1 showed modest clinical effects of the SSRI escitalopram given over 12 months compared with placebo and problem-solving therapy. However, comparing the design of this study and its positive results with another poststroke depression study of the same group with negative results2 raises important questions.