To the Editor: Dr Robinson and colleagues1 reported that poststroke patients randomized to either escitalopram or problem-solving therapy had a lower annual incidence of depression compared with those prescribed placebo. Although the authors discussed the finding that both treatments outperformed placebo, they did not make a direct statistical comparison between the active treatments. It would be valuable to know how psychosocial treatment compared with prescription medication.
Lacasse J, Leo J. Escitalopram, Problem-Solving Therapy, and Poststroke Depression. JAMA. 2008;300(15):1757–1759. doi:10.1001/jama.300.15.1757-c