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October 15, 2008

Escitalopram, Problem-Solving Therapy, and Poststroke Depression—Reply

JAMA. 2008;300(15):1757-1759. doi:10.1001/jama.300.15.1758-b

In Reply: Drs Schulte-Herbrüggen and Röpke question whether the treatment with escitalopram may have provided some neuroprotective function through mechanisms such as neurogenesis or increase in neuropeptides that have been identified in animal models of neuropathology. We only assessed activities of daily living and cognitive function. We did not find any significant time × treatment interaction in Functional Independence Measure scores over the course of the year. We also found no significant differences in recurrent stroke or hospitalization for cardiovascular illness. It is possible, however, that longer-term follow-up may show lower differential rates of recurrence of stroke or cardiovascular morbidity or mortality.1