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The World in Medicine
October 15, 2008

Advanced Paternal Age

JAMA. 2008;300(15):1752. doi:10.1001/jama.300.15.1752-d

Offspring of older fathers are more likely to develop bipolar disorder than those of younger fathers, according to research by scientists from Sweden and England (Frans EM et al. Arch Gen Psychiatry. 2008;65[9]:1034-1040).

The nested case-control study, which used national Swedish registers, involved 13 428 patients with a diagnosis of bipolar disorder on at least 2 separate hospital admissions and healthy controls matched for sex and year of birth. The researchers found (after controlling for potential confounding factors) that children of men aged 55 years or older were 1.37 times more likely to be diagnosed with bipolar disorder than those of men aged 20 to 24 years.