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Lab Reports
November 5, 2008

Brain Tumor Genes

JAMA. 2008;300(17):1989. doi:10.1001/jama.2008.529

A search of cancer genes has uncovered a number of previously unknown mutations linked to the most common type of adult brain tumor that may help explain how the disease develops (The Cancer Genome Atlas Research Network. Nature. 10.1038/nature07385 [published online ahead of print September 4, 2008]).

Investigators within the Cancer Genome Atlas Research Network at 18 participating institutions and organizations published their interim analysis of DNA copy number, gene expression, and DNA methylation aberrations found in tumor samples from 206 patients with glioblastoma. They also reported nucleotide sequence aberrations in 91 of the 206 glioblastomas.