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November 5, 2008

Integrity of Active Components of Botanical Products Used in Complementary and Alternative Medicine—Reply

JAMA. 2008;300(17):1995-1996. doi:10.1001/jama.2008.558

In Reply: We agree with Dr Stoney and colleagues about the importance of documenting the integrity and stability of biologically active components in botanical products. In our study, we used a supplier (Vital Nutrients Inc, Middletown, Connecticut) that provided independent confirmation of the certificate of analysis data provided by the botanical grower. The supplier also provided 2-year stability data of hypericin content from a previous sample of H perforatum. We believed that we would have similar stability in the product used in our study.