In Reply: We agree with Dr Stoney and colleagues about the importance of documenting the integrity and stability of biologically active components in botanical products. In our study, we used a supplier (Vital Nutrients Inc, Middletown, Connecticut) that provided independent confirmation of the certificate of analysis data provided by the botanical grower. The supplier also provided 2-year stability data of hypericin content from a previous sample of H perforatum. We believed that we would have similar stability in the product used in our study.
Weber W, McClellan J. Integrity of Active Components of Botanical Products Used in Complementary and Alternative Medicine—Reply. JAMA. 2008;300(17):1995–1996. doi:10.1001/jama.2008.558
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