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November 5, 2008

Family History and Survival in Patients With Stage III Colorectal Cancer

JAMA. 2008;300(17):1996-1997. doi:10.1001/jama.2008.547

To the Editor: Dr Chan and colleagues1 studied the association between self-reported family history of colorectal cancer and survival in a cohort of patients with stage III colorectal cancer receiving adjuvant chemotherapy. Their conclusions were that cancer recurrence was lower and survival greater in patients with a positive family history. We believe that a flawed study design precludes reaching these conclusions.