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November 12, 2008

Depressive Symptoms and Diabetes

JAMA. 2008;300(18):2115-2116. doi:10.1001/jama.2008.565

To the Editor: In their longitudinal cohort study, Dr Golden and colleagues1 reported an inverse association between impaired fasting glucose and depressive symptoms; a positive association was identified between treated type 2 diabetes and the development of depressive symptoms. A complementary analysis showed a significantly higher incidence of type 2 diabetes among participants with elevated depressive symptoms. However, the authors did not report whether there was an association between baseline depressive symptoms and the incidence of impaired fasting glucose. This is important because early identification of prediabetes and subsequent intervention with lifestyle modifications or pharmacotherapy (eg, metformin) may reduce the onset of type 2 diabetes.2

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