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November 12, 2008

Carotid Endarterectomy and Statin Therapy in the Management of Patients With Carotid Artery Disease

JAMA. 2008;300(18):2117-2119. doi:10.1001/jama.2008.583

To the Editor: In his Clinical Crossroads article, Dr Caplan1 discussed a 70-year-old man with coronary, aortic, and peripheral arterial disease who had an episode of brain ischemia caused by severe preocclusive internal carotid disease. Caplan recommended treatment with a high dose of statin (atorvastatin, 80 mg daily). However, this is based on extrapolation from studies of younger patients and does not consider adverse effects.