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November 19, 2008

Association of Fetuin-A Level and Diabetes Risk

JAMA. 2008;300(19):2247-2248. doi:10.1001/jama.2008.614

To the Editor: In the case-cohort study of participants in the Health, Aging, and Body Composition (ABC) Study, Dr Ix and colleagues1 found that higher circulating levels of the liver-derived protein fetuin-A were associated with increased risk of developing type 2 diabetes in older individuals. Although fetuin-A was positively correlated with the amount of visceral fat assessed by computed tomographic scanning, the relationship to incident diabetes was only marginally attenuated after adjustment for visceral adiposity. Adjustment for the circulating adipokines adiponectin and leptin, as well as for circulating cytokines, did not affect the results, suggesting an independent effect of fetuin-A on diabetes risk.