To the Editor: In their randomized controlled trial, Dr Nurnberg and colleagues1 showed that sildenafil can be an effective option for the treatment of selective or nonselective serotonin reuptake inhibitor (SRI)–induced sexual dysfunction in women. However, treating one medication-induced adverse effect with another medication is not the only treatment option available. This approach can further increase the occurrence of adverse effects and potentially augment patient drug costs.
Harinstein L. Sildenafil as Treatment for Antidepressant-Induced Sexual Dysfunction. JAMA. 2008;300(20):2365–2366. doi:10.1001/jama.2008.692