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Comment & Response
February 12, 2014

Acute Muscle Wasting Among Critically Ill Patients

Author Affiliations
  • 1Clinical Research Centre, Kingston General Hospital, Kingston, Ontario, Canada

Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2014;311(6):622. doi:10.1001/jama.2013.285423

To the Editor Muscle wasting in critically ill patients is both pervasive and detrimental. Dr Puthucheary and colleagues1 attempted to characterize the muscle wasting process and its sequelae in critically ill patients from both a clinical and molecular perspective. Unfortunately their report contained several statistical inconsistencies.

Some 95% confidence intervals presented in the body of the article were inconsistent with Figure 2; and some confidence intervals contained zero and were thus inconsistent with statistically significant change despite P values of less than .05. In addition, Figures 2, 3, and 5 appear to be reporting means rather than medians.