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Comment & Response
February 19, 2014

Short-Acting β-Blocker Administration in Patients With Septic Shock

Author Affiliations
  • 1Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
JAMA. 2014;311(7):735-736. doi:10.1001/jama.2014.324

To the Editor The study by Dr Morelli and colleagues1 evaluated the effect of short-acting β-blocker (esmolol) administration in patients with septic shock; however, we have some problems with their interpretation of the results.

First, stroke volume and left ventricular stroke work index (without any difference in arterial pressure) moved in parallel in the 2 groups. Analysis of the area under the curve (AUC) is frequently used in studies of drug pharmacokinetics, but in this case, a simple visual exploration (Figure 3 in article) does not support the reported differences because the baseline values were quite different.

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