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December 10, 2008

Silver-Coated Endotracheal Tubes and Patient Outcomes in Ventilator-Associated Pneumonia

JAMA. 2008;300(22):2605-2606. doi:10.1001/jama.2008.760

To the Editor: In their study of the North American Silver-Coated Endotracheal Tube (NASCENT) randomized trial, Dr Kollef and colleagues1 concluded that silver-coated endotracheal tubes reduced the incidence of ventilator-associated pneumonia (VAP) by 36% compared with uncoated tubes. The evidence they present, however, is more suggestive of an effect on endobronchial colonization than on clinically meaningful invasive disease.

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