In Reply: Dr Scott and colleagues highlight one of the issues raised by our Editorial: problems related to the accuracy of measurement of blood glucose in the critically ill. They suggest that imprecision of bedside blood glucose measurement may be the predominant reason why subsequent studies and indeed the pooled results in the meta-analysis by Weiner et al1 were not able to confirm the substantial reduction in mortality found in the original study of intensive insulin therapy reported by van den Berghe et al.2
Finfer S, Delaney A. Tight Glucose Control in Critically Ill Adults—Reply. JAMA. 2008;300(23):2725–2728. doi:10.1001/jama.2008.820
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