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January 21, 2009

Allopurinol and the Role of Uric Acid in Hypertension—Reply

JAMA. 2009;301(3):270-271. doi:10.1001/jama.2008.1014

In Reply: The purpose of our study was to investigate the role of uric acid in the pathogenesis of essential hypertension. As described in the article, it was predicated on numerous studies showing that an elevated uric acid level predicts the development of hypertension in the general population, the presence of hyperuricemia in 90% of adolescents with newly diagnosed essential hypertension, and the finding that raising uric acid causes hypertension in animals. Our short-term study resulted in normal blood pressure in 86% of hypertensive participants when their uric acid level was lowered to less than 5.0 mg/dL vs 3% when they received placebo treatment. (To convert uric acid to μmol/L, multiply by 59.485.)