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February 25, 1998

Stress Linked to Immune Response

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Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998American Medical Association

JAMA. 1998;279(8):574. doi:10.1001/jama.279.8.574-JQU81031-2-1

The stress of being diagnosed with breast cancer can weaken the immune system in some women, according to researchers at Ohio State University in Columbus.

In a study of 116 women who underwent surgery for stage II or stage III breast cancer, the researchers divided participants into a low-stress group and a high-stress group. They found that women in the high-stress group experienced an increased breakdown of natural killer (NK) cells and had a lower response to interferon gamma, which enhances NK cell activity. Women in the high-stress group also had lower T-lymphocyte responses to monoclonal antibodies. The findings were reported January 7 in the Journal of the National Cancer Institute.

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