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To the Editor A retrospective cohort study by Dr Vigen and colleagues1 evaluated the association between testosterone therapy for men with total testosterone levels of less than 300 ng/dL and a composite outcome (all-cause mortality, myocardial infarction, and stroke). Flaws in the design and population of this study may have affected the validity of the conclusions drawn by Vigen et al.1
Riche DM, Baker WL, Koch CA. Deaths and Cardiovascular Events in Men Receiving Testosterone. JAMA. 2014;311(9):963–964. doi:10.1001/jama.2014.386
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