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May 13, 2009

Antioxidant Supplementation and Cancer Prevention

JAMA. 2009;301(18):1877-1879. doi:10.1001/jama.2009.629

To the Editor: In his Editorial accompanying 2 randomized trials of antioxidant supplementation for prostate cancer prevention, Dr Gann1 discussed the low numbers of deaths from prostate cancer in one of these studies, SELECT.2 He stated that based on population death rates, 75 to 100 deaths from prostate cancer would have been expected, whereas only a single death was observed, noting that “[e]ven allowing for the requirement of a normal PSA [prostate-specific antigen] and rectal examination at entry, that is an enormous deficit in expected mortality.”