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The World in Medicine
October 14, 1998

Antifreeze Antidote

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JAMA. 1998;280(14):1216. doi:10.1001/jama.280.14.1216-JWM80007-5-1

Researchers in France have reported the successful use of a new antidote for ethylene glycol poisoning in children.

In the September 3 issue of Pediatrics, the researchers described their use of an alcohol dehydrogenase inhibitor, 4-methylpyrazole (4-MP), with a 4-year-old girl who swallowed a potentially lethal dose of ethylene glycol contained in automobile antifreeze. Intravenous infusion of the 4-MP was given 7 hours after the girl ingested the antifreeze. She received an initial loading dose administered during a 1-hour period and two maintenance doses given 12 and 24 hours later, respectively.