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Health Agencies Update
October 21, 1998

Cerebral Palsy Clues

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JAMA. 1998;280(15):1298. doi:10.1001/jama.280.15.1298-JHA80008-4-1

Inflammation and blood clotting abnormalities may play an important role in the pathogenesis of cerebral palsy (CP) in full-term infants, according to a new study led by researchers at the National Institute of Neurological Disorders and Stroke (Ann Neurol. 1998;44:665-667).

In the study, the investigators tested blood samples collected from infants shortly after birth—archival samples originally collected for routine screening for metabolic disorders—for levels of cytokines, known to be markers of inflammation, as well as coagulation factors. Thirty-one of the samples were from children who had developed CP (most of whom had been born full-term and had no clear explanation for the disorder) and 65 who had not developed the condition.