To the Editor: There is an increasing incidence of community-acquired Clostridium difficile infection (CDI) among patients regarded as low risk because they were not exposed to antimicrobial therapy.1 In his Clinical Crossroads article discussing CDI, Dr Kelly2 did not mention the potential role of the excess use of proton pump inhibitors (PPIs) in hospitals and in the community.
Famularo G, Gasbarrone L, De Simone C. Proton Pump Inhibitors and the Risk for Clostridium difficile Infection. JAMA. 2009;302(1):31–32. doi:https://doi.org/10.1001/jama.2009.901
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