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September 22/29, 1999

Enzyme Deficit May Cause SIDS

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JAMA. 1999;282(12):1121. doi:10.1001/jama.282.12.1121-JQU90007-3-1

Some of the mystery behind sudden infant death syndrome may be explained by an enzyme deficiency, according to a new study.

In the July/August issue of Pediatric and Developmental Pathology, researchers at the University of Texas Southwestern Medical Center reported that a deficiency in short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase (SCHAD) may be responsible for a small portion of otherwise unexplained deaths in children younger than 1 year old. The researchers studied 150 infant deaths and found the deficiency present in 2% of the cases.